ME/CFS Science @mecfsscience.org · 14/06/20262) They have an interest in GLP-1 RA because it affects biological pathways that come up in the ME/CFS genes they identified such as synaptic and calcium signalling, glucose homeostatis and endothelial dysfunction. 160
ME/CFS Science @mecfsscience.org · 14/06/20263) In a previous analysis they also looked at genes that are protective for ME/CFS and several were involved in type-2 diabetes, insulin-related signalling, BMI, etc. That's another reason why they are interested in the GLP-1 drugs. Link:sciencedirect.comActively protective combinatorial analysis: A scalable novel method for detecting variants that contribute to reduced disease prevalence in high-risk individualsWe present a novel method for routinely identifying disease resilience associations that offers powerful insights for the discovery of a new class of … 181
ME/CFS Science @mecfsscience.org · 14/06/20264) Because of the heterogeneity in ME/CFS, different drugs will work for different people - no single trial will benefit everyone. For GLP-1 RA, they recommend focusing on three subgroups: autoimmune/inflammatory, cardiovascular and/or energy metabolism. 1103
