ME/CFS Science @mecfsscience.org · 18/05/202611) This replication is important because it shows it’s not just about one study (DecodeME) or one approach (GWAS of common variants) anymore, but multiple genetic databases and techniques pointing to neurons and synapses. 2191
ME/CFS Science @mecfsscience.org · 18/05/202612) I think tissue results were largely similar to those from DecodeME, highlighting various brain regions such as the hypothalamus, hippocampus and cerebellum. But using gene expression databases, Paolo also found significant hits for particular brain cell types. 1151
ME/CFS Science @mecfsscience.org · 18/05/202613) One is called “ the eccentric medium spiny neuron (eMSN) in the claustrum.” These have only recently been discovered and have been associated with educational attainment, intelligence, and neuropsychiatric disorders. 3181
