ME/CFS Science @mecfsscience.org · 18/05/20269) Then Paolo replicated his results in another genetic study, the preprint by Mark Snyder’s group at Stanford (Zhang et al. 2025 ). Instead of common DNA variants, it looked at rare mutations using a machine learning algorithm. 1130
ME/CFS Science @mecfsscience.org · 18/05/202610) Paolo checked if these results match the gene categories on synapses. They did: seven of the 12 BH-significant gene sets were replicated in the Snyder study. 1130
ME/CFS Science @mecfsscience.org · 18/05/202611) This replication is important because it shows it’s not just about one study (DecodeME) or one approach (GWAS of common variants) anymore, but multiple genetic databases and techniques pointing to neurons and synapses. 2191
