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ME/CFS Science @mecfsscience.org · 17/05/2026

5) Some questionnaires did hint at lower orthostatic symptoms for ivabradine, particularly on the orthostatic grading scale (but it seems that the study didn't correct for multiple comparisons). A reduction in heart rate but not symptoms was also reported by the RECOVER trial.

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ME/CFS Science @mecfsscience.org · 17/05/2026

6) These results could mean that the high heart rate in POTS isn't strongly connected to most of the symptoms and disability that patients experience. We wrote about this hypothesis here, but acknowledge that more data is needed to clarify this issue:

mecfsscience.org

The problems with POTS - ME/CFS Science

The diagnostic criteria for postural orthostatic tachycardia syndrome (POTS) have been questioned by several researchContinue readingThe problems with POTS

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ME/CFS Science @mecfsscience.org · 17/05/2026

7) There are major limitations to this study. The sample size was small (only 28 female POTS patients), and there was a high drop-out rate of around 32% (the trial started with 37 participants). The authors didn't use an intention-to-treat analysis and ignored the dropouts.

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