ME/CFS Science @mecfsscience.org · 17/05/20262) The study was a crossover trial, meaning all participants got the 3 treatments: ivabradine (5 mg), propranolol (4 x 10 mg), or placebo in consecutive order with a 7-day washout period in between. Each treatment period lasted 28 days. 180 0
ME/CFS Science @mecfsscience.org · 17/05/20263) Ivabradine got slightly better results, so let's zoom in on its comparison to the placebo. The graph below shows a very notable effect on heart rate during a 10-minute head-up tilt test. The mean heart rate was also 15 bpm lower in 24-hour Holter monitor recordings. 190 0
ME/CFS Science @mecfsscience.org · 17/05/20264) Ivabradine also increased systolic blood pressure (bit of a surprise), but there was no obvious effect on symptoms. The authors used questionnaires such as the RAND-36, COMPASS-31, and the Vanderbilt Orthostatic Symptom Score (VOSS), with no clear overall effect on either. 180 0
