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ME/CFS Science @mecfsscience.org · 15/05/2026

4) The authors highlight correlations between muscaranic autoantibodies and cognitive performance but they had a lot of clinical measures and didn't correct for multiple comparisons so have doubts if this is significant Higher antibodies were correlated with better performance.

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ME/CFS Science @mecfsscience.org · 15/05/2026

5) Some limitations of the study: the samples were not matched for age and sex (95% of ME/CFS was female compared to 77% in controls), they used the outdated Fukuda criteria (where PEM is not required) and medication use wasn't controlled for.

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FunkisHen @funkishen.bsky.social · 15/05/2026

What's even the point of studying "ME" if you're not actually studying ME? Fukuda has PEM as optional, thus rendering this study useless since you can't differentiate people with chronic fatigue and ME. This study tells us nothing, because we can't know what their participants actually suffer from.

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Ona Albizu - PhD MSc BD @onaalbizu.bsky.social · 30/05/2026

Thanks for this!! I know this was mentioned to them by patients, but...

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ME/CFS Science @mecfsscience.org · 15/05/2026

6) In our review of the immune system in ME/CFS, we wrote that the evidence for these autoantibodies wasn't very convincing and think this study adds further evidence for this.

mecfsscience.org

The immune system in ME/CFS - ME/CFS Science

In this article, we have made a comprehensive overview of research findings on the immuneContinue readingThe immune system in ME/CFS

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Wilhelmina Jenkins @wilhelminaj.bsky.social · 15/05/2026

Please - no more Fukuda!!

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