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ME/CFS Science @mecfsscience.org · 06/05/2026

7) They did find that people in the early onset are more severely affected, have more family members with ME/CFS and are more likely to report an infectious trigger. The latter was particularly the case for glandular fever although this didn’t fully explain the difference.

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ME/CFS Science @mecfsscience.org · 06/05/2026

8 ) Ryback suggests that future studies should take age of onset into consideration when stratifying cohorts and looking at subgroups. As a next step, she is currently looking at electronic healthcare records in the UK and the diagnoses that precede ME/CFS.

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Simon McGrath @simonmcg.bsky.social · 06/05/2026

Audrey will also analyse data from the Action for ME big survey which included questions on trigger types, whether onset was sudden or gradual, and explore in more detail whether or not people have relatives with the ill illness.

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ME/CFS Science @mecfsscience.org · 06/05/2026

9) Link to the interview: www.youtube.com/watc... Link to the paper: academic.oup.com/ooi... Link to blog post by first author Simon Mcgrath explaining the results: mecfsresearchreview....

youtube.com

Interview with University of Edinburgh immunologist Audrey Ryback

The journal Oxford Open Immunology recently published paper an interesting paper titled “Cases of Incidence age is bimodal for myalgic encephalomyelitis/chronic fatigue syndrome, with higher severity burden for early onset disease.” According to the abstract, “findings suggest that incidence of ME/C

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