ME/CFS Science @mecfsscience.org · 21/04/20265) But they don't think this is a big issue: "while these methodological constraints are important to note, they represent inherent challenges of the field rather than fatal flaws that would completely invalidate the clinical value of these trials." 2121
ME/CFS Science @mecfsscience.org · 21/04/20266) That seems to be the most crucial line in the whole review. At least the authors are upfront with it! We disagree and think it likely is a fatal flaw. For more info on why blinding is important, see this brief history that we wrote about it here:mecfsscience.orgTurning a blind eye to blinding - ME/CFS ScienceBlinding is the process of keeping key persons involved in the conduct of a clinical trial unaware of group assignment. 1205
ME/CFS Science @mecfsscience.org · 21/04/20267) Bias would explain why the positive effects of exercise are only seen on subjective such as questionnaire, and not objective outcomes such as fitness tests. When exercise was proposed in ME/CFS more than 30 years ago, the main rationale was reversing deconditioning. 1171
