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ME/CFS Science @mecfsscience.org · 03/04/2026

9) The objective measure in the AUTONOMIC group was an improvement of 10 beats per minute (or 10mmHg in systolic blood pressure or 5 mmHg in diastolic BP) on a standing test. This was the case for 11.8% in the Paxlovid group and 15.4% in the placebo group (p: 0.412).

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ME/CFS Science @mecfsscience.org · 03/04/2026

10) The POST-EXERTIONAL MALAISE group looked at the percentage with no symptoms of moderate or greater severity with 50% or more frequency on the DSQ-PEM short form. This was 25.5% in the Paxlovid group and 33.3% in the placebo group (p: 0.186).

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ME/CFS Science @mecfsscience.org · 03/04/2026

11) The objective measure in the POST-EXERTIONAL MALAISE group was the percentage with an improvement of at least 3 minutes on the endurance shuttle walk test. Here, the Paxlovid actually did significantly worse: 16.7% versus 30.6% (p-value: 0.014).

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