iiinova — where your digital self keeps evolving

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ME/CFS Science @mecfsscience.org · 01/04/2026

1) 🇧🇷 A big trial from Brazil reports that the antidepressant fluvoxamine improved fatigue in Long Covid patients while the diabetes drug Metformin had no effect. The effect of fluvoxamine unfortunately looks quite small and it's unclear if it is clinically significant.

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Magpie @conservationista.bsky.social · 01/04/2026

Oh, I remember a question from the ME Association about metformin and I replied that it had had no effect for me. I'd be interested in trying fluvoxamine. Very interesting. Thanks for sharing. I'll read more.

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ME/CFS Science @mecfsscience.org · 01/04/2026

2) This was a big trial with 150 participants getting fluvoxamine (100 mg twice daily), 111 metformin (750 mg twice daily), and 138 a matched placebo pill. The trial used Bayesian analysis with early stopping; they collected data until interim analyses showed a clear result.

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noseymole.bsky.social @noseymole.bsky.social · 01/04/2026

They excluded people who had mecfs and at the discretion of the investigators. The protocol is not available.

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