iiinova — where your digital self keeps evolving

Replies

ME/CFS Science @mecfsscience.org · 13/01/2026

5) Instead of CD20, plasma cells express the CD38 protein on their surface. By using daratumumab, which targets CD38, researchers hope to kill these plasma cells and stop the production of autoantibodies. Results from the pilot study were promising:

frontiersin.org

Frontiers | Plasma cell targeting with the anti-CD38 antibody daratumumab in myalgic encephalomyelitis/chronic fatigue syndrome—a clinical pilot study

BackgroundMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) entails low quality of life for patients and massive societal costs. There is an urgent...

1140

ME/CFS Science @mecfsscience.org · 13/01/2026

6) There are also plans to do a randomized, sham-controlled trial of immunoadsorption, which simply filters antibodies from the blood. If ME/CFS is caused by circulating auto-antibodies, this would also show an effect.

link.springer.com

IA-PACS-CFS: a double-blinded, randomized, sham-controlled, exploratory trial of immunoadsorption in patients with chronic fatigue syndrome (CFS) including patients with post-acute COVID-19 CFS (PACS-CFS)

Trials - Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severely debilitating condition which markedly restricts activity and function of affected people. Since the beginning of...

1130

ME/CFS Science @mecfsscience.org · 13/01/2026

7) Lastly, DecodeME will re-analyze the HLA-region which helps the immune system differentiate your own cells from foreign invaders. Pretty much all autoimmune diseases – multiple sclerosis, type 1 diabetes, psoriasis, Hashimoto’s, etc. – show an association with HLA-variants.

1191