ME/CFS Science @mecfsscience.org · 18/10/20251) Dr. Robert Naviaux’s theory is that the mitochondrial dysfunction observed in ME/CFS isn’t actually a dysfunction. The mitochondria are doing precisely as they are instructed by signals in the blood and from the brain. 23111
ME/CFS Science @mecfsscience.org · 18/10/20252) The mitochondria are not damaged or diseased. They are being actively down-regulated by signals in the blood to create a hypometabolic survival state similar to dauer. 1121
ME/CFS Science @mecfsscience.org · 18/10/20253) According to Naviaux, this is a reason for hope because it implies that the mitochondria and patients can recover. He thinks this physiologic state can be traced back to extracellular ATP signalling and that it can be dampened with antipurinergic drugs like suramin. 1110
