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ME/CFS Science @mecfsscience.org · 16/01/2025

3) A year later Japanese researchers used a different technique, next-generation sequencing, and also found that IGHV3-30 genes were more frequent in ME/CFS patients than in controls. www.sciencedirect.co...

sciencedirect.com

Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition characterized by fatigue and post-exertional malaise, accompan…

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ME/CFS Science @mecfsscience.org · 16/01/2025

4) They also found that IGHV3-30 was related to an infectious-onset and shorter illness duration. Here’s what their data looked like:

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ME/CFS Science @mecfsscience.org · 16/01/2025

5) It’s still unclear what the findings mean. IGHV-30 is normally associated with the production of antibodies in case of infection or autoimmunity but there were no clear signs of that in ME/CFS. There was no clonal expansion.

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