Cosmin Tudose @cosmintudose.bsky.social · 09/09/2025Naturally, we observed that some level of H3K27me3 is maintained in EZH2+/- and we found out that these maintained me3 peaks show distinctive characteristics. Firstly, these peaks are wider, covering a larger genomic area🧬. 8/17 100
Cosmin Tudose @cosmintudose.bsky.social · 09/09/2025Secondly, as observed in the Hi-C, these peaks are found in regions where there is high DNA-DNA contact frequency in all conditions, suggesting H3K27me3 is preferentially maintained at these hubs of compacted chromatin ➰➰➰. 9/17 100
Cosmin Tudose @cosmintudose.bsky.social · 09/09/2025Notably, we observed a compartmentalization change upstream of the LIN28B locus in the Hi-C data. While this locus did not show any significant change in H3K27me or H3K27ac, the LIN28B fetal oncogene was upregulated in our EZH2+/- cells. 10/17 100
