dfachinetti.bsky.social @dfachinetti.bsky.social · 04/09/2025#4 We show that loss of DNAme leads to disruption of the centromere’s bipartite structure and also controls the presence of another centromere-associated protein, CENP-B. Excessive CENP-B makes centromeric DNA more fragile and prone to breakage. 100 1
dfachinetti.bsky.social @dfachinetti.bsky.social · 04/09/2025#5 We also found that gradual methylation loss allows most cells to adapt and survive, whereas rapid loss causes aneuploidy and cell death. This slow adaptation mirrors what often happens during cancer progression. 100 1
dfachinetti.bsky.social @dfachinetti.bsky.social · 04/09/2025#6 In summary, this work carried out at @institutcurie.bsky.social @cnrs.fr @stanforduniversity.bsky.social and supported by @agencerecherche.bsky.social @fondationarc.bsky.social @chanzuckerberg.bsky.social provides the first evidence that DNA methylation directly influences centromere function 110 1
