#4 We also found that this surveillance mechanism is activated in aging-related setting, such as in a disease condition called progeria, which is characterized by altered assembly of the nuclear lamina at the cellular level #5 While the sensing of nuclear mechanical alterations limits the proliferation of abnormal cells, we find that the increased in nuclear flexibility enhances the ability of aneuploid cells to deform and invade complex environments, a process that may promote metastasis in p53 deficient context