David Warner (he/him) @davidwarner2.bsky.social · 27/12/2024🧠 Tyrosine hydroxylase (requires iron) 👃There are juxtaglomerular neurons that release dopamine and modulate the release of glutamate from olfactory receptor neurons, inhibiting smell 👃Dopamine is made from tyrosine via tyrosine hydroxylase 100
David Warner (he/him) @davidwarner2.bsky.social · 27/12/2024🍫 Interference with these inhibitory pathways in IDA may lead to an increased desire to smell specific odors (desiderosmia) 🍫Desiderosmia is most commonly reported in pregnancy, which can cause harm to mom/baby 🍫Tx: treat underlying IDA Other clinical applications of iron's role in smell: 100
David Warner (he/him) @davidwarner2.bsky.social · 27/12/2024🧠Welders working in poorly ventilated settings have a decreased sense of smell compared to the general population 🧠Parkinson's and Alzheimer's Disease are associated with increased iron deposits in the CNS and may explain why loss of smell is a feature of both diseases 100
