Nejc Haberman @nejchaberman.bsky.social · 15/11/20242/10 CAGE profiling often reveals signals (~10-15%) in 3′UTRs — regions far from usual transcription start sites (TSS). This phenomenon is reproducible but poorly understood. 100
Nejc Haberman @nejchaberman.bsky.social · 15/11/20243/10 It has been suggested that 3′UTR CAGE signals arise from post-transcriptional cleavage followed by capping of exposed 5′ ends. These processes might lead to independent, functional 3′UTR-derived RNAs. 100
Nejc Haberman @nejchaberman.bsky.social · 15/11/20244/10 By analysing our data alongside #ENCODE & #FANTOM datasets, we provide direct evidence that these 3′UTR-derived RNAs are capped, reproducible, conserved across mammals, and detectable via long-read sequencing. 100
