I really recommend checking out the work of Peter Levine (the father of “Somatic Experiencing”) when it comes to stress management. His hypothesis is that unlike in the natural world, under capitalism the stress never goes “away,” so the nervous system cannot regulate/return to homeostasis.
To be more precise about it, there are studies examining the impact of burnout on the prefrontal cortex and amygdala. Thankfully there are also studies that suggest that recovery is possible but they still need to be replicated.
If you’re a game dev, here are some resources: