Miguel López Rivera @riveralopz.bsky.social · 29/05/2026(3/6) RyDEP turns immune signal destruction into a metabolic opportunity: it hydrolyzes the unique ribose–ribose bond in Thoeris signals, generating ADPR that the NARP1 pathway can use to rebuild NAD. The phage can turn a host immune signal into something useful for itself! 130 0
Miguel López Rivera @riveralopz.bsky.social · 29/05/2026(4/6) Then the structure gave us a huge surprise. RyDEP shares remarkable homology with the Repeat12 domain of animal RyRs, giant calcium-release channels. Since cADPR has long been linked to RyR regulation, this opens a new path to ask how human RyR domains sense cADPR-like signals. 110 0
Miguel López Rivera @riveralopz.bsky.social · 29/05/2026(5/6) Finally, RyDEP revealed a bigger family. Diverse phage RyR-domain proteins bind Thoeris signals without cleaving them, acting as tight-binding sponges that evade defense by sequestration. Same fold, different ways to disarm immunity. 120 0