Gonzalo Borrego-Yaniz @goboru.bsky.social · 16/04/2026For this study, we tested genome-wide sex-specific associations, and we found novel (and sex-specific) genetic associations for both males and females 🔝 100
Gonzalo Borrego-Yaniz @goboru.bsky.social · 16/04/2026And even more interestingly (to me at least), we found that some previously described associations of SSc are actually only associated to women! But as sex-bias had not been considered in GWAS before, the higher incidence of SSc in females made it so they were identified as shared SSc risk variants 100
Gonzalo Borrego-Yaniz @goboru.bsky.social · 16/04/2026How many of the genetic associations in previous studies in autoimmune diseases are actually sex-dependent? This study highlights the importance of studying genomics in a sex-aware manner 100
