Amazing work. Direct imaging evidence that DNA sequence and TFBS number and composition at enhancers are responsible for non-uniform nuclear TF concentrations, sth I've suspected for a while(tinyurl.com/TFhubs)! Highlights the importance of TF cooperativity! Time to study this in more detail :)
@mirlab.bsky.social1/ Our paper, “Enhancer binding kinetics explain transcription factor hub formation,” is now published! Here we set out to understand why transcription factors form bright clusters or “hubs” in the nucleus, and whether those hubs actually control gene activity.
tinyurl.com/38uf8348
tinyurl.com
Enhancer binding kinetics explain transcription factor hub formation
Transcription factors (TFs) form dynamic, high-concentration clusters, condensates, or hubs, proposed to increase TF binding frequency at target enhancers. However, how enhancer sequence shapes hub pr...