"Our findings argue against a strict reg. role for TAD boundaries in controlling gene expression [...] TADs appear to serve primarily to organize chrom. topology at a global scale"- taking it as support from the '3Ders' for my love of TFs as prime regulatory suspects😉
www.biorxiv.org/content/10.6...
biorxiv.org
TAD boundary architecture and gene activity are uncoupled
Topologically associating domains (TADs) are prominent features of genome organization. A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD...