Very much into this! "Future work will clarify the biochemical basis for how promoter-proximal elements, like SRR2, synergize with distal enhancers to support cohesin-independent long-range regulation."
@benoitbruneau.bsky.socialBah, who needs cohesin if you're at the right place (near). Grover once taught us the difference between near and far (my favourite Sesame Street piece), and now amazing work from @elphegenoralab.bsky.social led by @karissalhansen.bsky.social shows us how: www.science.org/doi/10.1126/...
science.org
Synergy between regulatory elements can render cohesin dispensable for distal enhancer function
Enhancers are critical genetic elements controlling transcription from promoters, yet how they convey regulatory information across large genomic distances remains unclear. Here, we engineer pluripote...