IOCB Prague @iocbprague.bsky.social · 05/10/2026⚗️ Researchers led by Paulo Paioti from IOCB Prague have developed a new catalytic macrocyclization strategy for synthesis of cyclic molecules that are difficult to obtain by conventional methods... 🧵 #organicsynthesis #research #IOCB #IOCBPrague 110 0
IOCB Prague @iocbprague.bsky.social · 05/10/2026The approach enables the direct formation of sterically hindered carbon–nitrogen bonds through an intramolecular nucleophilic aromatic substitution (SNAr) reaction and provides access to highly strained atropisomeric macrocycles, medium-sized rings and atropopeptides. 100 0
IOCB Prague @iocbprague.bsky.social · 05/10/2026The key innovation lies in the way the reaction generates and regenerates a strong base. In many base-catalyzed substitution reactions, catalyst turnover is inefficient because the leaving group is not sufficiently basic. 100 0
