Depending on the kind of analysis you're doing, you may be interested in checking out molly. It's a very fast reader and writer for XTC files I created and maintain.
For example, molly can often skip reading solvent through clever buffering. And it has python bindings.
github.com/ma3ke/molly
github.com
GitHub - ma3ke/molly: Read xtc files, fast.
Read xtc files, fast. Contribute to ma3ke/molly development by creating an account on GitHub.
