Manuel Thery @manuelthery.bsky.social · 20/05/2026this sounds familiar to me ;-) but the actin signal is low at the BB, and rather surrounds it, which is not suggestive of nucleation from BB itself. 100 0
kuba sędziński @kuba-sedzinski.bsky.social · 20/05/2026This is difficult to say, but indeed it is more likely that the actin network acts as a surrounding viscoelastic meshwork that constrains basal body motion through steric hindrance, frictional coupling, and transient physical interactions that ultimately generate cages around BBs. 100 0
kuba sędziński @kuba-sedzinski.bsky.social · 20/05/2026In fact, in a-actinin 1 KD, there are no cages around BBs, which itself suggests that it is the apical actin network that gets reorganised through x-linking, thereby creating the pockets in which BBs get stuck. 000 0
