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Roby Bhattacharyya @roby-b.bsky.social · 02/09/2025

Oh man, I think I may have a new figure to open a lot of my talks with...

From graphical abstract of the linked paper: a plot of an interrupted time series analysis showing an abrupt increase in genomic antibiotic resistance elements (among cultured bacteria, which will often be from clinical samples) starting the year that the given antibiotic was introduced into clinical practice.

What was antibiotic resistance like before we ever used antibiotics? How did we change what antibiotic resistance genes looked like over 100 years? Our paper looking at resistance genes from a century of NCTC historical isolates now out in mGen: www.microbiologyresearch.org/content/jour...

microbiologyresearch.org

Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibiotics

Antibiotic resistance is frequently observed shortly after the clinical introduction of an antibiotic. Whether and how frequently that resistance occurred before the introduction is harder to determin...

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Kevin Outterson @koutterson.bsky.social · 08/09/2025

Another gem: "The widespread prevalence of genomic resistance elements observed, therefore, likely reflects intrinsic resistance elements rather than acquired or emergent resistance mechanisms."

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