iiinova — where your digital self keeps evolving

Replies

Joseph Mikhael MD @jmikhaelmd.bsky.social · 24/09/2025

2/ Before we jump in, a few disclosures & important links🔗 1️⃣📖#CME info bonumce.short.gy/NDMM-TW1-CME 2️⃣Take the pre-survey 👉bonumce.short.gy/NDMM-TW1-Pre 3️⃣Get the latest NDMM quad tx efficacy data w/ 🧵👇 4️⃣🏆Claim🆓CME bonumce.short.gy/NDMM-TW1-Post Now, let's get started!

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Joseph Mikhael MD @jmikhaelmd.bsky.social · 24/09/2025

3/🥼In your practice, which regimen are you using most often for 1L therapy in pts w/ transplant eligible (TE) #NDMM? ☎️ #MedSky #HemeSky 💬 reply and let us know what you do in your practice? 1️⃣ DVRd quad 2️⃣ IsaVRd quad 3️⃣ DKRd or IsaKRd quad 4️⃣ VRd 5️⃣ other triplet

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Joseph Mikhael MD @jmikhaelmd.bsky.social · 24/09/2025

4/💃Quads are taking center stage in NDMM Let’s look @ the📈 on quad tx PERSEUS ~🔑 trial: SQ dara➕VRd ➡️ ↑outcomes in TE pts 👉↑PFS @ 48m 84.3 v 67.7%; HR: 0.42; P<0.001 👉↑MRD- rate 75.2 v 47.5%; P<0.001 👉↑CR rate 87.9 v 70.1%; P<0.001 🎉 🆕 SOC ~ quad instead of triplet 🎉

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