iiinova — where your digital self keeps evolving

Replies

Ryan Emenecker @remenecker.bsky.social · 27/02/2026

We also designed additional sequences with designated ensemble dimensions and explored the relationship between sequence dimensions and in-cell crowding, see thread from @trevorbrandt.bsky.social for more on this (bsky.app/profile/trev...).

trevorbrandt.bsky.social@trevorbrandt.bsky.social

(1/7) New preprint, check it out! "Rational design of disordered proteins for systematic sequence-to-function investigation" www.biorxiv.org/content/10.1...

biorxiv.org

100

Ryan Emenecker @remenecker.bsky.social · 27/02/2026

We then design a 2-component in-cell recruitment system in which one IDR forms cellular assemblies, and another is targeted to (or excluded from) those assemblies, all using de novo IDRs designed from scratch (200- and 400-residue proteins).

110

Ryan Emenecker @remenecker.bsky.social · 27/02/2026

Finally, we designed a library of >2000 sequence variants to systematically explore the molecular determinants of how disordered proteins convey desiccation tolerance in yeast. See thread from @karaehunt.bsky.social for more on this (bsky.app/profile/kara...).

karaehunt.bksy.social

@karaehunt.bsky.social@karaehunt.bsky.social

After over 2 years - our new preprint is finally out! “Rational design of disordered proteins for systematic sequence-to-function investigation”! www.biorxiv.org/content/10.1...

biorxiv.org

100