Zeyun Lu 鲁泽沄 @zeyunlu.bsky.social · 05/01/2026We also identify cases where Mr. PEG uniquely implicates PTGS2 as a mediating gene for gout, suggesting potential opportunities for drug repurposing. (10/n) 110
Zeyun Lu 鲁泽沄 @zeyunlu.bsky.social · 05/01/2026Mr. PEG is open-source command-line Python software, implemented in JAX with JIT compilation for fast inference: github.com/gusevlab/mrpeg (11/n)github.comGitHub - gusevlab/mrpeg: The python software to run mpeg framework.The python software to run mpeg framework. Contribute to gusevlab/mrpeg development by creating an account on GitHub. 141
Zeyun Lu 鲁泽沄 @zeyunlu.bsky.social · 05/01/2026Overall, our results highlight the value of integrating experimental trans effects with population-scale GWAS and eQTL data to identify disease-relevant mediating genes beyond single loci. (12/n) 110
