Zeyun Lu 鲁泽沄 @zeyunlu.bsky.social · 05/01/2026These mediating genes are more constrained than background genes and show distinct epigenetic features compared to genes prioritized by GWAS hits, MR-based methods, or burden tests. (8/n) 110
Zeyun Lu 鲁泽沄 @zeyunlu.bsky.social · 05/01/2026Notably, Mr. PEG effects learned from common-variant GWAS are associated with rare coding burden effects, capturing disease mechanisms missed by cis-eQTL-only approaches. (9/n) 110
Zeyun Lu 鲁泽沄 @zeyunlu.bsky.social · 05/01/2026We also identify cases where Mr. PEG uniquely implicates PTGS2 as a mediating gene for gout, suggesting potential opportunities for drug repurposing. (10/n) 110
