Zeyun Lu 鲁泽沄 @zeyunlu.bsky.social · 05/01/2026Recent work shows systematic differences between cis-eQTL and GWAS signals, supporting models where upstream genes regulate downstream genes, ultimately affecting disease through complex regulatory cascades. (3/n) 121
Zeyun Lu 鲁泽沄 @zeyunlu.bsky.social · 05/01/2026Perturbational screens (e.g., Perturb-seq) combine CRISPR screens with scRNA-seq to estimate gene-to-gene effects, providing more direct evidence for causal trans regulation than association-based trans-eQTLs. (4/n) 110
Zeyun Lu 鲁泽沄 @zeyunlu.bsky.social · 05/01/2026Mr. PEG unifies MR-like tests with experimental data by modeling GWAS signals as a function of eQTL effects of perturbed genes × gene-to-gene effects learned from perturbational screens. (5/n) 110
