akhiad.bsky.social @akhiad.bsky.social · 17/10/2025For example, when modelling regulation of Epiblast to Mesoderm differentiation in mouse embryos, we can explain changes in accessibility with only 13 TF motif models! 7/ 100
akhiad.bsky.social @akhiad.bsky.social · 17/10/2025Here are 3 biological insights derived from IQ (before we reflect on what’s in it for the non-biologist crowd). Insight 1: Sequence defines regulatory intensity over a quantitative spectrum – not a binary yes/no classifier. IQ can predict this spectrum! 8/ 100
akhiad.bsky.social @akhiad.bsky.social · 17/10/2025Insight 2: TFs care about sub-optimal binding sites. IQ integrates strong and weak TF-DNA interactions. This reveals that TFs 'read' sequences in different ways – some care only for the best targets and others integrate many weak ones. 9/ 100
