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ME/CFS Science @mecfsscience.org · 03/04/2026

11) The objective measure in the POST-EXERTIONAL MALAISE group was the percentage with an improvement of at least 3 minutes on the endurance shuttle walk test. Here, the Paxlovid actually did significantly worse: 16.7% versus 30.6% (p-value: 0.014).

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ME/CFS Science @mecfsscience.org · 03/04/2026

12) Otherwise, the number of adverse events seems low and similar in the groups, so I don't think this was a major issue in the trial. There was no mortality, and around 4-5% in each group had ‘Serious Adverse Events’.

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ME/CFS Science @mecfsscience.org · 03/04/2026

13) Overall, this seems like pretty convincing evidence that Paxlovid doesn’t work to treat Long Covid symptoms such as PEM, cognitive dysfunction, or orthostatic intolerance.

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